Structure of PDB 8sp8 Chain D

Receptor sequence

>8sp8D (length=612) Species: 9606 (Homo sapiens)

ESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRG
AMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVV
NQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSE
EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHG
DHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTST
LYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGR
PYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEA
YMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFH
VLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLG
PFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDY
PMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIA
MMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLG
DRWFLRVEDRQD

3D structure

• PDB: 8sp8 Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin.
• Chain: D
• Resolution: 2.79 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	I8E	D	I564 T567 L568	I538 T541 L542
BS02	I8E	D	I557 I564	I531 I538
BS03	Y01	D	I335 Y339 I394 G395 I398 E403 F425 H426 Y467 F468 M603	I309 Y313 I368 G369 I372 E377 F399 H400 Y441 F442 M577
BS04	Y01	D	F425 S455 F456 V459 L460 C463 M466 Y467 T479 Q483	F399 S429 F430 V433 L434 C437 M440 Y441 T453 Q457
BS05	Y01	D	C494 M497 D525 P527 F534	C468 M471 D499 P501 F508
BS06	I8E	D	L490 F493 M497 F534 L538 L573	L464 F467 M471 F508 L512 L547

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8sp8, PDBe:8sp8, PDBj:8sp8
• PDBsum: 8sp8
• PubMed: 37532722
• UniProt: Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)