Structure of PDB 8sml Chain D

Receptor sequence
>8smlD (length=570) Species: 9606 (Homo sapiens) [Search protein sequence]
GTLIRVTPEQPTHAVCVLGTLTQLDICSSASFSINASPGVVVDIAWPLDP
GVEVTLTMKAASGSTGDQKVQISYYKTPPVKALLYLTGVEISLCADITRT
WGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTP
KDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMV
PGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVV
FRVAPWIMTPNTQPPQEVYACNEDFLKSVTTLAMKAKCKLTICPEWMQDE
MEIGYIQAPHKTLPVVFDSPRRVMGPDFGYVTRGGLDSFGNLEVSPPVTV
RGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLS
VGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLIKNI
LSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKA
EAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTF
INDGTNVRRKPFSFKWWNMV
3D structure
PDB8sml Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA D N153 D155 D157 D165 D176 N113 D115 D117 D125 D136
BS02 CA D D155 D157 D179 D388 D115 D117 D139 D327
BS03 CA D D165 D168 E170 D125 D128 E130
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140794 histone arginine deiminase activity
GO:0140795 histone H3R2 arginine deiminase activity
GO:0140796 histone H3R8 arginine deiminase activity
GO:0140797 histone H3R17 arginine deiminase activity
GO:0140798 histone H3R26 arginine deiminase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0019827 stem cell population maintenance
GO:0036211 protein modification process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sml, PDBe:8sml, PDBj:8sml
PDBsum8sml
PubMed38308046
UniProtQ9UM07|PADI4_HUMAN Protein-arginine deiminase type-4 (Gene Name=PADI4)

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