Structure of PDB 8si5 Chain D

Receptor sequence
>8si5D (length=1097) Species: 10090 (Mus musculus) [Search protein sequence]
QKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHA
CFTASLAMKYSDVKLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSH
SYRAKYVRLSYDTKPEIILQLLLKEWQMELPKLVISVHGGMQKFELHPRI
KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTI
GIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGT
VGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLE
YLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKK
TFNFGQSEAVHLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALLKG
TNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRV
SFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLIRDVKQGNLP
PGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLETKRFPYPLNEL
LIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDT
SEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLA
VSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLE
YKTKAEMSHIPQSQLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVV
LVKMEQLPSVQEWIVIAYIFTYAIEKVREVFMSEAGKISQKIKVWFSDYF
NVSDTIAIISFFVGFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYV
RLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP
HEEPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTICGPGTWLTP
FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHE
KPVLPPPLIILSHIVSLFCCVCKGPKLFLTEEDQKKLHDFEEQCVEMYFD
EKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDS
3D structure
PDB8si5 Structural mechanisms of TRPM7 activation and inhibition.
ChainD
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DU0 D M868 Y973 M744 Y849
BS02 CLR D W1071 L1072 W947 L948
BS03 CLR D Y923 I970 F971 Y799 I846 F847
BS04 DU0 D S1029 W1030 S905 W906
BS05 ZY8 D M741 D745 M748 M753 M666 D670 M673 M678
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0051262 protein tetramerization
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8si5, PDBe:8si5, PDBj:8si5
PDBsum8si5
PubMed37156763
UniProtQ923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (Gene Name=Trpm7)

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