Structure of PDB 8rth Chain D

Receptor sequence
>8rthD (length=542) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
EVYLFHPAQYESAPATTRPNVLHYPAESTNPEFKANTERMKALTAELRRR
VQVIVDGDSEADKRARDRHISRGKLLVHQRIEKLVDPMSPFLELSQLAGG
DLYPGEACHRGGILTGIGVVHGMRVMIVANDATVKGGTYYPITVKKHLRA
QRIAEENRLPCIYLVDSGGANLGMQGDVFPDEQHFGRIFFNQANMSAKGI
AQIATVMGSCTAGGAYVPAMSDESIIVKGNGTIFLGGPPLVFAATGEEVT
PEELGGADVHCRASGVTDYFATDDLHALYLTRRIVANLNRNDCERPCRGR
EFTPPLYDPSEIGGFIPDMGADVVKGFDVRAVIARLVDGSEFDEFKKLYG
DTLVCGFARFEGMLVGIVANNGILYSESALKGAHFVELCSHRNIPLLFLQ
NITGFMVGKTYEEGGIAKNGAKLVTAVSTTHVPKITIIIGGSYGAGNYGM
CGRAFGPRFLFMWPNARISVMGGNQAATVLALTNSKLRENEVQDFKAKVR
SKYEYEGSCYYSTARLWDDGVIAPEDTRAVVVQALLSTLSAP
3D structure
PDB8rth The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function
ChainD
Resolution2.37 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI D T462 G463 F464 N533 Q534 T403 G404 F405 N474 Q475
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:1905202 methylcrotonoyl-CoA carboxylase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rth, PDBe:8rth, PDBj:8rth
PDBsum8rth
PubMed38593794
UniProtQ385A6

[Back to BioLiP]