Structure of PDB 8rqc Chain D

Receptor sequence
>8rqcD (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
PTSHTYLGADMEEFGRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHP
QEVSMVRNLIQNDRTFAVLAYSNVEREAEFGTTAEIYAYREEQDFGIEIV
KVKAIGRQRFKVLELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLRE
WDENLKDDSLPSNPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELD
IMNKCTSLCCKQCQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVY
KACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQK
FWGLTRSALIPT
3D structure
PDB8rqc Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
ChainD
Resolution2.15 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D N351 H353 Y355 W386 V388 A395 H397 W400 N238 H240 Y242 W273 V275 A282 H284 W287
BS02 ZN D C323 C326 C391 C394 C210 C213 C278 C281
BS03 QFC D F102 F150 I152 N351 P352 H353 E377 H378 S379 W380 W386 W400 F402 F48 F95 I97 N238 P239 H240 E264 H265 S266 W267 W273 W287 F289
External links
PDB RCSB:8rqc, PDBe:8rqc, PDBj:8rqc
PDBsum8rqc
PubMed
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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