Structure of PDB 8qns Chain D

Receptor sequence

>8qnsD (length=439) Species: 10090 (Mus musculus)

IRAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPL
SKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGV
AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGA
EVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQA
SGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVS
GGRLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNA
ELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKP
YWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFEDYGKGVIFYLRDKVVV
GIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED

3D structure

• PDB: 8qns Structural characterization of the interaction between apoptosis inducing factor (AIF) and CHCHD4.
• Chain: D
• Resolution: 3.206 Å

Enzymatic activity

• Enzyme Commision number: 1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y346 S499 S500 L501 P502 T503 V504 G505 V506 F507 E557 D558 Y559 K605	Y222 S375 S376 L377 P378 T379 V380 G381 V382 F383 E384 D385 Y386 K432
BS02	FAD	D	G137 G139 T140 A141 V161 E163 R171 P172 K176 K231 V232 T259 G260 R284 D437 E452 H453 H454 W482	G13 G15 T16 A17 V37 E39 R47 P48 K52 K107 V108 T135 G136 R160 D313 E328 H329 H330 W358
BS03	NAD	D	G307 G308 F309 L310 E313 P334 E335 K341 A396 V397 G398 L399 E452 H453 W482 S483	G183 G184 F185 L186 E189 P210 E211 K217 A272 V273 G274 L275 E328 H329 W358 S359

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046983 protein dimerization activity

External links

• PDB: RCSB:8qns, PDBe:8qns, PDBj:8qns
• PDBsum: 8qns
• UniProt: Q9Z0X1|AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial (Gene Name=Aifm1)