Structure of PDB 8qic Chain D

Receptor sequence
>8qicD (length=400) Species: 585034 (Escherichia coli IAI1) [Search protein sequence]
DHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQE
VKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFN
QGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQ
IRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLA
VALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSR
LSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQV
VIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPY
MLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE
3D structure
PDB8qic Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.3: threonine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VL0 D M91 C93 R122 M133 F138 Q140 D142 H144 Y221 K224 Q238 T241 Q243 H270 S276 M90 C92 R121 M132 F137 Q139 D141 H143 Y220 K223 Q237 T240 Q242 H269 S275
BS02 ZN D C93 H144 H270 C92 H143 H269
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004829 threonine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006435 threonyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8qic, PDBe:8qic, PDBj:8qic
PDBsum8qic
PubMed38558084
UniProtP0A8M3|SYT_ECOLI Threonine--tRNA ligase (Gene Name=thrS)

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