Structure of PDB 8q3i Chain D

Receptor sequence

>8q3iD (length=1272) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

DVNFFDELRIGLATADDIRNWSYGEVKKPETINYRTLKPEKDGLFCEKIF
GPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVT
HIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDDEMRHNELSTLE
AEMAVEKKAVEDQRDADLEARAQKLEADLAELEAEGAKSDVRRKVRDSGE
REMRQLRDRAQRELDRLDEIWNTFTKLAPKQLIVDEVLYRELQDRYGEYF
TGAMGAESIKKLIENFDIDAEAESLREVIRSGKGQKKLRALKRLKVVAAF
QQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNN
RLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSL
SDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELF
KPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAP
TLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQ
AEARILMLSSNNILSPASGKPLAMPRLDMVTGLYYLTTLVEGATGEYQAA
TKDAPEQGVYSSPAEAIMAMDRGALSVRAKIKVRLTELRPPTDLEAQLFE
NGWKPGDAWTAETTLGRVMFNELLPKSYPFVNEQMHKKVQARIINDLAER
FPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPQKQEILERHEAEA
DAIERKYQRGALNHTERNESLVKIWQDATEEVGKALEEFYPADNPIITIV
KSGATGNLTQTRTLAGMKGLVTNPKGEFIPRPIKSSFREGLTVLEYFINT
HGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCETERGINVTLAE
RGPDGTLIRDAHVETSAFARTLATDAVDANGNVIIERGHDLGDPAIDALL
AAGITTVKVRSVLTCTSATGVCAMCYGRSMATGKLVDIGEAVGIVAAQSI
GEPGTQLTMRTFHQIVGGLPRVQELFEARVPRNKAPIADVAGRVRLEESD
KFFKITIVPDDGGEEVVYDKLSKRQRLRVITHEDGTEGVLSDGDHVEVGD
QLMEGAADPHEVLRVQGPREVQIHLVKEVQEVYRAQGVSIHDKHIEVIVR
QMLRRVTIIDSGSTEFLPGSLTERAEFEAENRRVVAEGGEPAAGRPVLMG
ITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIP
AGTGISRYRNIQVQPTEEARAA

3D structure

• PDB: 8q3i Molecular insights into RNA polymerase recycling by mycobacterial HelD
• Chain: D
• Resolution: 3.11 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	C890 C967 C974 C977	C888 C965 C972 C975
BS02	ZN	D	C62 C75	C60 C73
BS03	MG	D	D535 D537 D539	D533 D535 D537

External links

• PDB: RCSB:8q3i, PDBe:8q3i, PDBj:8q3i
• PDBsum: 8q3i
• UniProt: A0QS66|RPOC_MYCS2 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)