Structure of PDB 8pr7 Chain D

Receptor sequence
>8pr7D (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIANF
GWAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAATYAET
YKRISRVEFAFPAFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANS
S
3D structure
PDB8pr7 Aurora-A in complex with CEP192 and an inhibitory monobody
ChainD
Resolution2.76 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D I135 F144 Y148 L149 R151 K156 I10 F19 Y23 L24 R26 K31
BS02 ADP D L139 G140 G142 K143 E211 Y212 A213 L14 G15 G17 K18 E86 Y87 A88
External links
PDB RCSB:8pr7, PDBe:8pr7, PDBj:8pr7
PDBsum8pr7
PubMed
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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