Structure of PDB 8pn9 Chain D

Receptor sequence
>8pn9D (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
SVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPF
NSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTI
LHLVVMNFVG
3D structure
PDB8pn9 Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B.
ChainD
Resolution3.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC D F51 P52 F53 F48 P49 F50
Gene Ontology
Molecular Function
GO:0008047 enzyme activator activity
Biological Process
GO:0001824 blastocyst development
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006915 apoptotic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0031647 regulation of protein stability
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8pn9, PDBe:8pn9, PDBj:8pn9
PDBsum8pn9
PubMed38670073
UniProtP61803|DAD1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Gene Name=DAD1)

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