Structure of PDB 8p5k Chain D

Receptor sequence
>8p5kD (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ
TLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM
RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPN
SIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSI
GTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPAATSAPLRQLLLA
LLQRNHKDRMDFDEFFHHPFLDA
3D structure
PDB8p5k Crystal structures of ULK1 in complex with KCGS compounds
ChainD
Resolution2.209 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HVH D I22 H24 A44 M92 E93 Y94 C95 G98 D102 L145 I15 H17 A37 M85 E86 Y87 C88 G91 D95 L138
BS02 MG D E191 Y198 D199 H263 E184 Y191 D192 H256
BS03 MG D H136 D165 F166 F168 H129 D158 F159 F161
External links
PDB RCSB:8p5k, PDBe:8p5k, PDBj:8p5k
PDBsum8p5k
PubMed
UniProtO75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Gene Name=ULK1)

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