Structure of PDB 8p0m Chain D

Receptor sequence
>8p0mD (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
TIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQDPPLEAVDVRQIYDK
FPEGGLKELYEKGPPNAFFLVKFWADLNSTIQEGAFYGVSSQYSSADSMT
ISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKL
KHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHH
VYKLVKD
3D structure
PDB8p0m Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
ChainD
Resolution1.961 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WCF D V266 Q270 I271 K274 K298 F299 W300 E392 V415 F416 E417 Y430 V42 Q46 I47 K50 K72 F73 W74 E164 V187 F188 E189 Y202
External links
PDB RCSB:8p0m, PDBe:8p0m, PDBj:8p0m
PDBsum8p0m
PubMed38565920
UniProtQ99594|TEAD3_HUMAN Transcriptional enhancer factor TEF-5 (Gene Name=TEAD3)

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