Structure of PDB 8ki3 Chain D

Receptor sequence

>8ki3D (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]

AATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGEST
VRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGP
IKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGG
AGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVIN
LKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDN
IFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSV
QAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRI
MDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRA
RKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAF
YMVGPIEEAVAKADKLAEEH

3D structure

PDB

8ki3 Structure of Mycobacterium tuberculosis ATP synthase

Chain

Resolution

2.89 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.2.2: H(+)-transporting two-sector ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	D	G162 G164 K165 T166 V167 Y348 F421 A424	G152 G154 K155 T156 V157 Y338 F411 A414

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity
GO:0042288	MHC class I protein binding
GO:0043532	angiostatin binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

	Biological Process
GO:0001525	angiogenesis
GO:0001649	osteoblast differentiation
GO:0006091	generation of precursor metabolites and energy
GO:0006629	lipid metabolic process
GO:0006754	ATP biosynthetic process
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0015986	proton motive force-driven ATP synthesis
GO:0042776	proton motive force-driven mitochondrial ATP synthesis
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0046034	ATP metabolic process
GO:0051453	regulation of intracellular pH
GO:0098761	cellular response to interleukin-7
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016469	proton-transporting two-sector ATPase complex
GO:0031090	organelle membrane
GO:0031966	mitochondrial membrane
GO:0042645	mitochondrial nucleoid
GO:0045259	proton-transporting ATP synthase complex
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0045267	proton-transporting ATP synthase, catalytic core
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ki3, PDBe:8ki3, PDBj:8ki3
PDBsum	8ki3
PubMed	38961288
UniProt	P06576\|ATPB_HUMAN ATP synthase subunit beta, mitochondrial (Gene Name=ATP5F1B)

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