Structure of PDB 8jma Chain D

Receptor sequence
>8jmaD (length=381) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MEISQPSIGIFYISKVLALAPYATVRNSKGRVEIGRSWLFTVYSATLTVV
MVFLTYRGLLFDANSEIPVRMKSATSKVVTALDVSVVVMAIVSGVYCGLF
SLNDTLELNDRLNKIDNTLNAYNNFRRDRWRALGMAAVSLLAISILVGLD
VGTWMRIAQDMNIAQSDTELNVHWYIPFYSLYFILTGLQVNIANTAYGLG
RRFGRLNRMLSSSFLAAAAKNKGLLLKSLADSHESLGKCVHLLSNSFGIA
VLFILVSCLLHLVATAYFLFLELLSKRDNGYLWVQMLWICFHFLRLLMVV
EPCHLAARESRKTIQIVCEIERKVHEPILAEAVKKFWQQLLVVDADFSAC
GLCRVNRTILTSFASAIATYLVILIQFQRTN
3D structure
PDB8jma Structural basis for sugar perception by Drosophila gustatory receptors.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FRU D R70 D83 D150 F178 Y182 H306 T310 Q330 W333 H337 R70 D83 D150 F178 Y182 H261 T265 Q285 W288 H292
Gene Ontology
Molecular Function
GO:0008527 taste receptor activity
GO:0033041 sweet taste receptor activity
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0170023 ionotropic sweet taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007635 chemosensory behavior
GO:0008049 male courtship behavior
GO:0008343 adult feeding behavior
GO:0032098 regulation of appetite
GO:0050909 sensory perception of taste
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0050916 sensory perception of sweet taste
GO:0060259 regulation of feeding behavior
GO:0071332 cellular response to fructose stimulus
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Cellular Component
External links
PDB RCSB:8jma, PDBe:8jma, PDBj:8jma
PDBsum8jma
PubMed38305684
UniProtQ9V4K2|GR43A_DROME Gustatory receptor for sugar taste 43a (Gene Name=Gr43a)

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