Structure of PDB 8j7d Chain D

Receptor sequence
>8j7dD (length=651) Species: 9606 (Homo sapiens) [Search protein sequence]
GRNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEA
YSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQE
GIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHA
RRIGYPVMIRIVRSEQEFQEQLESARRMLIEKFVDTPRHVEVQVFGDHHG
NAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYV
GAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGE
KIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRI
ETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLI
LKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAV
TYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILEN
TIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGD
KVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEE
E
3D structure
PDB8j7d Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI D M680 K681 M614 K615
Gene Ontology
Molecular Function
GO:0004075 biotin carboxylase activity
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006552 L-leucine catabolic process
GO:0006768 biotin metabolic process
GO:0009083 branched-chain amino acid catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j7d, PDBe:8j7d, PDBj:8j7d
PDBsum8j7d
PubMed
UniProtQ96RQ3|MCCA_HUMAN Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (Gene Name=MCCC1)

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