Structure of PDB 8j21 Chain D

Receptor sequence
>8j21D (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
NHWLVFSVYLFTFLVGLPLNLLALVIFVGKLRRRPVAVDVLLLNLTLSDL
LLLLFLPFRMVEAASGMHWPLPFILCPLSGFLFFTTIYLTALFLAAVSIE
RFLSVAYPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDTNGT
CYLEFREDQLAILLPVRLEMAVVLFGVPLLITSYCYSRLVWILGRGASHR
RRRRVAGLVAATLLNFLVCFGPYNVSHVVGYIQGESPVWRSYVLLLSTLN
SCVDPLVYYFSSSGFQADFHELLR
3D structure
PDB8j21 Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BUA D F96 R185 Y241 H245 R258 F84 R167 Y223 H227 R240
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0002376 immune system process
GO:0002385 mucosal immune response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0014061 regulation of norepinephrine secretion
GO:0032722 positive regulation of chemokine production
GO:0045776 negative regulation of blood pressure
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046885 regulation of hormone biosynthetic process
GO:0071398 cellular response to fatty acid
GO:0090276 regulation of peptide hormone secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j21, PDBe:8j21, PDBj:8j21
PDBsum8j21
PubMed38191689
UniProtO14843|FFAR3_HUMAN Free fatty acid receptor 3 (Gene Name=FFAR3)

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