Structure of PDB 8irk Chain D

Receptor sequence
>8irkD (length=372) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
MMMLAQQWRDARPKVAGLHLDSGACSRQSFAVIDATTAHARHEAEVGGYV
AAEAATPALDAGRAAVASLIGFAASDVVYTSGSNHAIDLLLSSWPGKRTL
ACLPGEYGPNLSAMAANGFQVRALPVDDDGRVLVDEASHELSAHPVALVH
LTALASHRGIAQPAAELVEACHNAGIPVVIDAAQALGHLDCNVGADAVYS
SSRKWLAGPRGVGVLAVRPELAERLQPRIPPSDWPIPMSVLEKLELGEHN
AAARVGFSVAVGEHLAAGPTAVRERLAEVGRLSRQVLAEVDGWRVVEPVD
QPTAITTLESTDGADPASVRSWLIAERGIVTTACELARAPFEMRTPVLRI
SPHVDVTVDELEQFAAALREAP
3D structure
PDB8irk Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE
ChainD
Resolution2.35 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP D G81 S82 N83 Y106 S155 D180 A182 S200 R202 K203 G82 S83 N84 Y107 S156 D181 A183 S201 R203 K204
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:1990411 hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8irk, PDBe:8irk, PDBj:8irk
PDBsum8irk
PubMed38072054
UniProtA0R5M7|EGTE_MYCS2 Probable hercynylcysteine sulfoxide lyase (Gene Name=egtE)

[Back to BioLiP]