Structure of PDB 8ir1 Chain D

Receptor sequence

>8ir1D (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]

ARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYA
VSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFA
PTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLV
VEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQ
RRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWT
ESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALR
APRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDK
AAAAAAAL

3D structure

PDB

8ir1 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	R33 I36 T42 R45 K46 N47 N48 R49 Q50 Y52 S55 H60 S63 S66 T69 R71 A72 V73 R75 P77 R80 G83 T84 R86 Q89 N94 M95 R97 G98 R100 M101 F102 A103 P104 K106 R109 R110 R114 N116 T118 Q119 K120 R121 K140 K163 T164 K165 K172 W177 K181 K182 R188 R190 A191 G192 K193 M196 R197 R199 R201 R204 R205 K219 R222 N223 L235 N236 K239 P242 G243 H245 R268 K274 R291 L293 K294 Q299 R300 P305 R306 K307 R312 L314 K316 K320 N321 L322 R323 L326 K327 K333 R336 T339 R342 Q343 N346 R350	R30 I33 T39 R42 K43 N44 N45 R46 Q47 Y49 S52 H57 S60 S63 T66 R68 A69 V70 R72 P74 R77 G80 T81 R83 Q86 N91 M92 R94 G95 R97 M98 F99 A100 P101 K103 R106 R107 R111 N113 T115 Q116 K117 R118 K137 K160 T161 K162 K169 W174 K178 K179 R185 R187 A188 G189 K190 M193 R194 R196 R198 R201 R202 K216 R219 N220 L232 N233 K236 P239 G240 H242 R265 K271 R288 L290 K291 Q296 R297 P302 R303 K304 R309 L311 K313 K317 N318 L319 R320 L323 K324 K330 R333 T336 R339 Q340 N343 R347
BS02	rna	D	A53 S55 K195 M196	A50 S52 K192 M193

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ir1, PDBe:8ir1, PDBj:8ir1
PDBsum	8ir1
PubMed	37491604
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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