Structure of PDB 8ipm Chain D

Receptor sequence
>8ipmD (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAY
ALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSM
QLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRT
YGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQ
RSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLE
DRIVKRFLLGISMLMWELIHKKVAKLRAAIKL
3D structure
PDB8ipm Structural insights reveal the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12S rRNA by methyltransferase METTL15
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D P136 D140 N143 A144 L145 Y157 F222 N225 P130 D134 N137 A138 L139 Y151 F216 N219
BS02 rna D H162 F193 P194 T200 R201 H156 F187 P188 T194 R195
BS03 SFG D T27 F28 G29 G32 H33 D50 R51 F77 D100 S104 E226 T21 F22 G23 G26 H27 D44 R45 F71 D94 S98 E220
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ipm, PDBe:8ipm, PDBj:8ipm
PDBsum8ipm
PubMed38291322
UniProtA6NJ78|MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (Gene Name=METTL15)

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