Structure of PDB 8i9o Chain D

Receptor sequence
>8i9oD (length=526) Species: 866768 (Escherichia coli 'BL21-Gold(DE3)pLysS AG') [Search protein sequence]
TTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGT
MSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLR
KERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESL
PFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSI
GIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLL
KSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIEL
PDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPG
GFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANS
TEFVPDCKYPVVALITEWRTMRLGAQQCQLVDDSLVRQLYNAPTIVERHR
HRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEF
TSTPRDGHPLFAGFVKAASEFQKRQA
3D structure
PDB8i9o Filamentation and inhibition of prokaryotic CTP synthase
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP D Q114 I116 Q113 I115
BS02 CTP D D147 I148 E149 D146 I147 E148
BS03 CTP D K187 T188 K189 K223 F227 K186 T187 K188 K222 F226
BS04 ADE D G17 R211 K239 D240 V241 I247 G16 R210 K238 D239 V240 I246
BS05 ONL D G351 G352 F353 C379 Q383 E403 H469 R470 Y471 G350 G351 F352 C378 Q382 E402 H451 R452 Y453
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003883 CTP synthase activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0097268 cytoophidium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i9o, PDBe:8i9o, PDBj:8i9o
PDBsum8i9o
PubMed38948148
UniProtP0A7E5|PYRG_ECOLI CTP synthase (Gene Name=pyrG)

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