Structure of PDB 8i1o Chain D

Receptor sequence
>8i1oD (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
HVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPC
YSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFIS
PFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIK
GFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPY
3D structure
PDB8i1o Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP D G52 G54 K55 T56 T57 I58 R158 V160 T194 T198 V199 G29 G31 K32 T33 T34 I35 R135 V137 T171 T175 V176
BS02 ADX D R82 F91 R96 N99 F121 I122 S123 P124 L163 G174 F175 R59 F68 R73 N76 F98 I99 S100 P101 L140 G151 F152
Gene Ontology
Molecular Function
GO:0004020 adenylylsulfate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000103 sulfate assimilation

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Molecular Function
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Biological Process
External links
PDB RCSB:8i1o, PDBe:8i1o, PDBj:8i1o
PDBsum8i1o
PubMed37207644
UniProtO95340|PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (Gene Name=PAPSS2)

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