Structure of PDB 8hvr Chain D

Receptor sequence
>8hvrD (length=1259) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
FDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTR
DWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWY
FKGVPSRLGYLLDLAPKDLEKVIYFAAYMITFVDEERRTRDLPSLEAHVS
VERQQIEQRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMK
QLRDRAQREIDRLDEVWNRFKNLKVQDLEGDELLYRELRDRFGTYFDGSM
GAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTS
NSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKR
LLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDML
KGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFV
MKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHR
LGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEAR
ILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDSEGRSPKGEGRAFGS
SAEAIMAFDAGDLTLQAKIDIRFPVGTIPPRGFEPPAREEGEPEWQQGDT
FTLKTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVNDLAERYPKVIVAA
TLDNLKAAGFFWATRSGVTVAISDIVVPDAKKEIVKGYEGQDEKVQKQYE
RGLITKEERTQELIAIWTKATNEVAEAMNDNFPKTNPVSMMVNSGARGNM
MQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLA
DTALRTADSGYLTRRLVDVSQDVIIREEDCGTERGLKLPIATRDADGTLR
KAEDVETSVYARMLAEDVVIDGKVIAPANVDLGDVLIDALVAHGVEEVKT
RSILTCESQVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTM
RTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRVRIEETEKT
KKIVVTPDDGSDETAFPISKRARLLVGEGDHVEVGQKLTVGATNPHDVLR
ILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDA
ELLPGELVERTKFETENRRVVQEGGHPASGRPQLMGITKASLATESWLSA
ASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVE
PTEEAKAAM
3D structure
PDB8hvr Structural basis of transcription activation by Streptomyces antibiotic regulatory protein family regulator AfsR
ChainD
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Y36 R37 P111 P122 K294 R389 Y30 R31 P105 P116 K288 R383
BS02 dna D K108 R334 R421 R427 A501 T862 A863 G866 Q1210 E1211 K102 R328 R415 R421 A495 T856 A857 G860 Q1204 E1205
BS03 MG D D535 D539 D529 D533
BS04 ZN D C60 C62 C75 C54 C56 C69
BS05 ZN D C886 C962 C969 C972 C880 C956 C963 C966
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hvr, PDBe:8hvr, PDBj:8hvr
PDBsum8hvr
PubMed38427710
UniProtQ8CJT1|RPOC_STRCO DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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