Structure of PDB 8hub Chain D

Receptor sequence
>8hubD (length=562) Species: 9606 (Homo sapiens) [Search protein sequence]
EFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPTTR
RYLQQLAEKPLETRTQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREP
DEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQM
HVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRGE
SVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRD
EWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFL
PLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWV
EEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVS
AFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPL
PEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCELAR
NSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQ
ELALITQAVQSE
3D structure
PDB8hub The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action.
ChainD
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.6: AMP deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H418 H420 H687 D764 H180 H182 H388 D465
BS02 N4X D L430 L502 I505 F506 S514 F518 S542 L554 W557 L192 L203 I206 F207 S215 F219 S243 L255 W258
Gene Ontology
Molecular Function
GO:0003876 AMP deaminase activity
GO:0019239 deaminase activity
Biological Process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0032264 IMP salvage

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8hub, PDBe:8hub, PDBj:8hub
PDBsum8hub
PubMed36563792
UniProtQ01433|AMPD2_HUMAN AMP deaminase 2 (Gene Name=AMPD2)

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