Structure of PDB 8hmb Chain D

Receptor sequence
>8hmbD (length=1253) Species: 9606 (Homo sapiens) [Search protein sequence]
RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVE
YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAIFD
VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY
AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVC
KPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW
IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE
DLKGYLDWITQAEDIWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIAS
EHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDC
FVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVAS
LLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFP
QSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI
LLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLFRLQCHRIVNDTIFT
NLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTLEIILKMT
AYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVL
RPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG
KLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLA
AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIII
AFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI
PKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNI
LNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSEV
NPAEHTSITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI
VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEA
WQDIMLACMPGKKCAPESEPCGSSFAVFYFISFYMLCAFLIINLFVAVIM
DNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP
CPHRVACKRLVSNATLFALVRTALRIKTEGNLEQANEELRAIIKKLLDQV
VPP
3D structure
PDB8hmb Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AC8 D V1053 T1056 T1057 F1129 S1132 M1177 M1178 F1181 M1509 A1512 F1513 V730 T733 T734 F806 S809 M854 M855 F858 M1135 A1138 F1139
BS02 CA D E363 E706 E1135 E231 E513 E812
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030315 T-tubule
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098839 postsynaptic density membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hmb, PDBe:8hmb, PDBj:8hmb
PDBsum8hmb
PubMed38555290
UniProtA0A0A0MSA1

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