Structure of PDB 8hkj Chain D

Receptor sequence
>8hkjD (length=419) Species: 1396 (Bacillus cereus) [Search protein sequence]
VSAIPQPKTYGPLGNLPLIDKDKPTLSFIKIAEEYGPIFQIQTLSDTIIV
VSGHELVAEVCDETRFDKSIEGALAKVRAFAGDGLFTSETHEPNWKKAHN
ILMPTFSQRAMKDYHAMMVDIAVQLVQKWARLNPNENVDVPEDMTRLTLD
TIGLCGFNYRFNSFYRETPHPFITSMTRALHDIQSMFSLVDNIIAEENDL
LSRMLNVPDPETGEKLDDENIRFQIITFLIAGHETTSGLLSFAIYFLLKN
PDKLKKAYEEVDRVLTDPTPTYQQVMKLKYMRMILNESLRLWPTAPAFSL
YAKEDTVIGGKYPIKKGEDRISVLIPQLHRDKDAWGDNVEEFQPERFEEL
DKVPHHAYKPFGNGQRACIGMQFALHEATLVMGMLLQHFELIDYQNYQLD
VKQTLTLKPGDFKIRILPR
3D structure
PDB8hkj Investigating the applicability of the CYP102A1-decoy-molecule system to other members of the CYP102A subfamily.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D K72 L89 F90 W99 A268 G269 T272 T273 L276 A332 F335 P397 F398 R403 C405 I406 G407 F410 A411 K68 L85 F86 W95 A231 G232 T235 T236 L239 A295 F298 P360 F361 R366 C368 I369 G370 F373 A374
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:8hkj, PDBe:8hkj, PDBj:8hkj
PDBsum8hkj
PubMed37167731
UniProtQ81BF4|C102_BACCR Bifunctional cytochrome P450/NADPH--P450 reductase (Gene Name=CYP102A5)

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