Structure of PDB 8hgg Chain D

Receptor sequence
>8hggD (length=1484) Species: 9606 (Homo sapiens) [Search protein sequence]
PSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYD
KCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYL
PGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGG
SALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDN
VKHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYN
QLSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNIS
WELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRH
LRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPH
RAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLG
GIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEP
SFETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDD
CTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLE
WFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPRE
AEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLV
PESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIR
LWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDP
PLQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIH
GSGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYF
HDGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVII
GQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQ
PMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNN
PLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSC
PELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSV
TVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCR
HPAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCREN
KHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTC
DPPPPKFHGLYQCTNGFQFNSECRIKCLGSNVIHCRKDGTWNGSFHVVPN
ELNSNLKLQCPDGYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPT
RVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGD
CCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEH
3D structure
PDB8hgg Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
ChainD
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.79: pappalysin-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H482 H486 H492 H470 H474 H480
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:8hgg, PDBe:8hgg, PDBj:8hgg
PDBsum8hgg
PubMed36550107
UniProtQ13219|PAPP1_HUMAN Pappalysin-1 (Gene Name=PAPPA)

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