Structure of PDB 8hd8 Chain D

Receptor sequence
>8hd8D (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNP
WHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPL
TFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLI
ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWL
IGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADGEF
3D structure
PDB8hd8 Crystal structure of TMPRSS2 in complex with 212-148
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.122: transmembrane protease serine 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBS D D435 S436 C437 Q438 S441 W461 G462 G464 D180 S181 C182 Q183 S186 W206 G207 G209
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8hd8, PDBe:8hd8, PDBj:8hd8
PDBsum8hd8
PubMed37990007
UniProtO15393|TMPS2_HUMAN Transmembrane protease serine 2 (Gene Name=TMPRSS2)

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