Structure of PDB 8h2h Chain D

Receptor sequence
>8h2hD (length=599) Species: 1358 (Lactococcus lactis) [Search protein sequence]
MKPTMAILERISKNSQENIDEVFTRLYRYLLRPDIYYVAYQNLYSNKGAS
TKGILDDTADGFSEEKIKKIIQSLKDGTYYPQPVRRMYIAKKNSKKMRPL
GIPTFTDKLIQEAVRIILESIYEPVFEDVSHGFRPQRSCHTALKTIKREF
GGARWFVEGDIKGCFDNIDHVTLIGLINLKIKDMKMSQLIYKFLKAGYLE
NWQYHKTYSGTPQGGILSPLLANIYLHELDKFVLQLKMKFDRESPERITP
EYRELHNEIKRISHRLKKLEGEEKAKVLLEYQEKRKRLPTLPCTSQTNKV
LKYVRYADDFIISVKGSKEDCQWIKEQLKLFIHNKLKMELSEEKTLITHS
SQPARFLGYDIRVRRSGTIKRSGKVKKRTLNGSVELLIPLQDKIRQFIFD
KKIAIQKKDSSWFPVHRKYLIRSTDLEIITIYNSELRGICNYYGLASNFN
QLNYFAYLMEYSCLKTIASKHKGTLSKTISMFKDGSGSWGIPYEIKQGKQ
RRYFANFSECKSPYQFTDEISQAPVLYGYARNTLENRLKAKCCELCGTSD
ENTSYEIHHVNKVKNLKGKEKWEMAMIAKQRKTLVVCFHCHRHVIHKHK
3D structure
PDB8h2h Functionalized graphene grids with various charges for single-particle cryo-EM.
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D M1 K2 I7 R10 N14 R25 R32 K75 D76 Y80 R154 W155 K185 K195 H349 R365 R395 Q406 K408 N453 Y454 S486 M1 K2 I7 R10 N14 R25 R32 K75 D76 Y80 R154 W155 K185 K195 H349 R365 R395 Q406 K408 N453 Y454 S486
BS02 rna D N450 Y457 S476 N450 Y457 S476
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006314 intron homing
GO:0006397 mRNA processing
GO:0006974 DNA damage response

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Molecular Function
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Biological Process
External links
PDB RCSB:8h2h, PDBe:8h2h, PDBj:8h2h
PDBsum8h2h
PubMed36344519
UniProtP0A3U0|LTRA_LACLC Group II intron-encoded protein LtrA (Gene Name=ltrA)

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