Structure of PDB 8gvx Chain D

Receptor sequence

>8gvxD (length=686) Species: 9606 (Homo sapiens)

RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRV
TIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDP
ILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELE
IILNHRDDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWV
VKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFL
FMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFT
EYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIA
EALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVL
LAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWS
VFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY
QLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSLIQNQHYQEVIR
NLVKRYVAAMIRNTEENFKELKQDISSFRYEVLDLL

3D structure

• PDB: 8gvx Molecular architecture of the G alpha i -bound TRPC5 ion channel.
• Chain: D
• Resolution: 3.91 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YZY	D	F599 T603 T607 V610 I611	F571 T575 T579 V582 I583
BS02	Y01	D	Y316 L493 A499 N500	Y288 L465 A471 N472
BS03	ZN	D	H172 C178 C181	H156 C162 C165
BS04	CA	D	E418 E421 N436 D439	E390 E393 N408 D411
BS05	YZY	D	L514 L521 Y524 Q573 F576	L486 L493 Y496 Q545 F548

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8gvx, PDBe:8gvx, PDBj:8gvx
• PDBsum: 8gvx
• PubMed: 37137991
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)