BioLiP

PDB

8gsq Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.

Chain

Resolution

2.1 Å

3D
structure

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Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

H63 H71 H80 D83

H64 H72 H81 D84

Molecular Function

GO:0004784

superoxide dismutase activity

copper ion binding

protein binding

zinc ion binding

antioxidant activity

oxidoreductase activity

GO:0030346

protein phosphatase 2B binding

GO:0031267

small GTPase binding

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

GO:0046872

metal ion binding

GO:0051087

protein-folding chaperone binding

	Biological Process
GO:0000302	response to reactive oxygen species
GO:0000303	response to superoxide
GO:0001541	ovarian follicle development
GO:0001819	positive regulation of cytokine production
GO:0001890	placenta development
GO:0001895	retina homeostasis
GO:0002262	myeloid cell homeostasis
GO:0006749	glutathione metabolic process
GO:0006801	superoxide metabolic process
GO:0006879	intracellular iron ion homeostasis
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0007283	spermatogenesis
GO:0007566	embryo implantation
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008089	anterograde axonal transport
GO:0008090	retrograde axonal transport
GO:0008217	regulation of blood pressure
GO:0008340	determination of adult lifespan
GO:0009408	response to heat
GO:0009410	response to xenobiotic stimulus
GO:0010467	gene expression
GO:0019226	transmission of nerve impulse
GO:0019228	neuronal action potential
GO:0019430	removal of superoxide radicals
GO:0032287	peripheral nervous system myelin maintenance
GO:0032930	positive regulation of superoxide anion generation
GO:0033081	regulation of T cell differentiation in thymus
GO:0035234	ectopic germ cell programmed cell death
GO:0040014	regulation of multicellular organism growth
GO:0042542	response to hydrogen peroxide
GO:0042554	superoxide anion generation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0045471	response to ethanol
GO:0046620	regulation of organ growth
GO:0046716	muscle cell cellular homeostasis
GO:0048538	thymus development
GO:0048678	response to axon injury
GO:0050665	hydrogen peroxide biosynthetic process
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0051093	negative regulation of developmental process
GO:0051881	regulation of mitochondrial membrane potential
GO:0060047	heart contraction
GO:0060052	neurofilament cytoskeleton organization
GO:0060087	relaxation of vascular associated smooth muscle
GO:0060088	auditory receptor cell stereocilium organization
GO:0072593	reactive oxygen species metabolic process
GO:0099610	action potential initiation
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000242	negative regulation of reproductive process

Biological Process

GO:0000302

response to reactive oxygen species

GO:0000303

response to superoxide

GO:0001541

ovarian follicle development

GO:0001819

positive regulation of cytokine production

GO:0001890

placenta development

GO:0001895

retina homeostasis

GO:0002262

myeloid cell homeostasis

GO:0006749

glutathione metabolic process

GO:0006801

superoxide metabolic process

GO:0006879

intracellular iron ion homeostasis

GO:0006915

apoptotic process

GO:0006979

response to oxidative stress

GO:0007283

spermatogenesis

GO:0007566

embryo implantation

GO:0007605

sensory perception of sound

GO:0007626

locomotory behavior

GO:0008089

anterograde axonal transport

GO:0008090

retrograde axonal transport

GO:0008217

regulation of blood pressure

GO:0008340

determination of adult lifespan

GO:0009408

response to heat

GO:0009410

response to xenobiotic stimulus

GO:0010467

gene expression

GO:0019226

transmission of nerve impulse

GO:0019228

neuronal action potential

GO:0019430

removal of superoxide radicals

GO:0032287

peripheral nervous system myelin maintenance

GO:0032930

positive regulation of superoxide anion generation

GO:0033081

regulation of T cell differentiation in thymus

GO:0035234

ectopic germ cell programmed cell death

GO:0040014

regulation of multicellular organism growth

GO:0042542

response to hydrogen peroxide

GO:0042554

superoxide anion generation

GO:0043065

positive regulation of apoptotic process

GO:0043066

negative regulation of apoptotic process

GO:0043087

regulation of GTPase activity

GO:0043410

positive regulation of MAPK cascade

GO:0043524

negative regulation of neuron apoptotic process

GO:0045471

response to ethanol

GO:0046620

regulation of organ growth

GO:0046716

muscle cell cellular homeostasis

GO:0048538

thymus development

GO:0048678

response to axon injury

GO:0050665

hydrogen peroxide biosynthetic process

GO:0050728

negative regulation of inflammatory response

GO:0050766

positive regulation of phagocytosis

GO:0051093

negative regulation of developmental process

GO:0051881

regulation of mitochondrial membrane potential

GO:0060047

heart contraction

GO:0060052

neurofilament cytoskeleton organization

GO:0060087

relaxation of vascular associated smooth muscle

GO:0060088

auditory receptor cell stereocilium organization

GO:0072593

reactive oxygen species metabolic process

GO:0099610

action potential initiation

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO:2000242

negative regulation of reproductive process

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0032839	dendrite cytoplasm
GO:0032991	protein-containing complex
GO:0043025	neuronal cell body
GO:0070062	extracellular exosome
GO:1904115	axon cytoplasm

Cellular Component

extracellular region

extracellular space

nucleus

nucleoplasm

cytoplasm