Structure of PDB 8gru Chain D

Receptor sequence
>8gruD (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
SFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL
EQVLSSMKENKVAIIGKIHTLASYDMRLRRKLDLFANVVHVKSLPGYMTR
HNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDY
ATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCC
MQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFE
TGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIK
VGKVRTSDMGGYATCHDFTEEICRRVKDLDEN
3D structure
PDB8gru Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
ChainD
Resolution2.847 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD D N186 I215 N218 N166 I195 N198
BS02 NAD D A254 G255 H275 P276 F277 N287 D328 A234 G235 H255 P256 F257 N267 D308
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:8gru, PDBe:8gru, PDBj:8gru
PDBsum8gru
PubMed36375638
UniProtO43837|IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Gene Name=IDH3B)

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