Structure of PDB 8g9v Chain D

Receptor sequence

>8g9vD (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]

GNIILEILLLLITIIYSYLESLVRRKSVAGEIVLITGAGHGIGRQTTYEF
AKRKSRLVLWDINKHGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQ
VKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALL
PSMMKRNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL
GKTGIKTSCLCPVFVNTGFTKVLETDEVVRSLIDGILTNKKMIFVPSYIN
IFLRLQKFLPERASAILNRMQNIQFEAVVG

3D structure

PDB

8g9v Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.

Chain

Resolution

2.645 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.1.1.-
1.1.1.105: all-trans-retinol dehydrogenase (NAD(+)).
1.1.1.62: 17beta-estradiol 17-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	D	G43 H46 G47 I48 D67 I68 V92 D93 C94 N120 A121 G122 S172 Y185 K189 P218 F220 V221 T223 F225	G37 H40 G41 I42 D61 I62 V86 D87 C88 N114 A115 G116 S166 Y179 K183 P212 F214 V215 T217 F219
BS02	YYC	D	S172 V173 C174 I179 Y185 V219 F220 F225 I263 F266	S166 V167 C168 I173 Y179 V213 F214 F219 I249 F252

External links

PDB	RCSB:8g9v, PDBe:8g9v, PDBj:8g9v
PDBsum	8g9v
PubMed	37620305
UniProt	Q7Z5P4\|DHB13_HUMAN 17-beta-hydroxysteroid dehydrogenase 13 (Gene Name=HSD17B13)

[Back to BioLiP]