Structure of PDB 8fy2 Chain D

Receptor sequence
>8fy2D (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
VYDNREIVMKYIHYKLSQRGYEWDGPVPPVVHLTLRQAGDDFSRRYRRDF
AEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESV
NREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
3D structure
PDB8fy2 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
ChainD
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YFH D D103 F104 R107 Y108 E114 N143 W144 G145 A149 L201 Y202 D41 F42 R45 Y46 E52 N81 W82 G83 A87 L139 Y140
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8fy2, PDBe:8fy2, PDBj:8fy2
PDBsum8fy2
PubMed38548768
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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