Structure of PDB 8fy1 Chain D

Receptor sequence
>8fy1D (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
TGYDNREIVMKYIHYKLSQRGYEWDAGSPVPPVVHLTLRQAGDDFSRRYR
RDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCV
ESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSM
3D structure
PDB8fy1 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
ChainD
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YF8 D F104 R107 Y108 D111 F124 R129 T132 V133 E136 N143 W144 G145 R146 V148 E152 F198 L201 Y202 P204 S205 F45 R48 Y49 D52 F65 R70 T73 V74 E77 N84 W85 G86 R87 V89 E93 F139 L142 Y143 P145 S146
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8fy1, PDBe:8fy1, PDBj:8fy1
PDBsum8fy1
PubMed38548768
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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