Structure of PDB 8fq8 Chain D

Receptor sequence
>8fq8D (length=270) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKPQKSKPLTVERMVSPIESAEDLSKQTEIAYGTLDSG
STKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL
LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKL
SEQGVLDKLKNKWWYDKGEC
3D structure
PDB8fq8 The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
ChainD
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYZ D I481 S729 K730 G731 I89 S226 K227 G228
BS02 GLU D Y450 P478 T480 R485 S654 T655 E705 Y58 P86 T88 R93 S151 T152 E202
BS03 CYZ D P494 M496 S497 S754 L759 D760 P102 M104 S105 S251 L256 D257
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fq8, PDBe:8fq8, PDBj:8fq8
PDBsum8fq8
PubMed38409505
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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