Structure of PDB 8fpf Chain D

Receptor sequence

>8fpfD (length=666) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGIE
KTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVD
QAVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVL
LIALYGGLLVFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYF
DNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVK
LAFVALAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMTI
IQAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFVA
LIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELARV
SAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHISF
TAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQE
LRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKK
LPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDQATAHIDTET
EAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEEL
MALEGQYYQMYELQKG

3D structure

• PDB: 8fpf Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
• Chain: D
• Resolution: 3.27 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	D	Y439 V445 S467 G468 K469 S470	Y438 V444 S466 G467 K468 S469

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8fpf, PDBe:8fpf, PDBj:8fpf
• PDBsum: 8fpf
• PubMed: 37938578
• UniProt: O07549|YHEH_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (Gene Name=yheH)