Structure of PDB 8fn7 Chain D

Receptor sequence
>8fn7D (length=47) Species: 9606,11698 [Search protein sequence]
NFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKII
3D structure
PDB8fn7 Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D W243 E246 A248 R263 W22 E25 A27 R42
BS02 dna D R228 R263 R7 R42
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:8fn7, PDBe:8fn7, PDBj:8fn7
PDBsum8fn7
PubMed37478179
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
P42166

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