Structure of PDB 8fmv Chain D

Receptor sequence

>8fmvD (length=665) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGI
EKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFV
DQAVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMV
LLIALYGGLLVFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRY
FDNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIFTALFLLDV
KLAFVALAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMT
IIQAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFV
ALIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELAR
VSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS
FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQ
ELRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLK
KLPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDQATAHIDTE
TEAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEE
LMALEGQYYQMYELQ

3D structure

• PDB: 8fmv Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
• Chain: D
• Resolution: 3.34 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	D	Y439 V445 T465 G466 G468 K469 S470 S471 Y480	Y439 V445 T465 G466 G468 K469 S470 S471 Y480
BS02	HT1	D	H338 R345 N380 Q384	H338 R345 N380 Q384

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8fmv, PDBe:8fmv, PDBj:8fmv
• PDBsum: 8fmv
• PubMed: 37938578
• UniProt: O07549|YHEH_BACSU Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH (Gene Name=yheH)