Structure of PDB 8fhw Chain D

Receptor sequence
>8fhwD (length=432) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
LIVVSNRLPVTIGGLVSALFTWIGWPGKDIPMDRETVNRRLLDEYCYPVY
LSDELADSHYNGFSNSILWPLFHYHPGEMNFDAAHWLAYREANMRFADVV
SSLVQAGDMVWVQDYHLMLLPMLLRSMIRIGFFLHTPFPSSEIYRILPVR
REILLGVLQCDLIGFHTYDYARHFLSSCTRILGLETQPNGIEFDGRYCQV
GTFPIGIDPNQFIEGLQKESIVKRLRSLEARFEGVKVIIGVDRLDYIKGI
PQKLQALETFLTQHPEWIGKVVLVQLAIPSRQDVEEYQDLRACVNELVGR
INGRFGTVESVPIHYMHKSVPFEELTAMYALADACLVTSTRDGMNLVAYE
YISSQAERHGSMILSEFAGAAQSFNGSLLINPWDVQSTADAINQALTLSP
QQRKTNWQKLFNYVSKYTAEAWGVSFVNELNR
3D structure
PDB8fhw Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP D R415 K420 I450 S491 V492 L497 E522 R243 K248 I278 S319 V320 L325 E350
BS02 G6P D W151 R415 R453 W69 R243 R281
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004805 trehalose-phosphatase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0005992 trehalose biosynthetic process
GO:0034605 cellular response to heat
GO:0070413 trehalose metabolism in response to stress
Cellular Component
GO:0005829 cytosol
GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)

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Cellular Component
External links
PDB RCSB:8fhw, PDBe:8fhw, PDBj:8fhw
PDBsum8fhw
PubMed36993618
UniProtJ9VJZ1

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