Structure of PDB 8fgt Chain D

Receptor sequence

>8fgtD (length=402) Species: 9606 (Homo sapiens)

FPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRAPEQLLSQAR
DFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAI
TVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHG
WTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGL
RWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILED
VAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFM
KHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPD
PW

3D structure

• PDB: 8fgt Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.
• Chain: D
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.39: nitric-oxide synthase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	H4B	D	W445 F460 E463	W367 F382 E385
BS02	ZN	D	C94 C99	C27 C32
BS03	HEM	D	W178 A181 R183 C184 V185 G186 S226 F353 S354 G355 W356 E361 W447 F473 Y475	W100 A103 R105 C106 V107 G108 S148 F275 S276 G277 W278 E283 W369 F395 Y397
BS04	H4B	D	S102 R365 A446 W447	S35 R287 A368 W369
BS05	XVK	D	P334 V336 F353 S354 E361	P256 V258 F275 S276 E283

Gene Ontology

Molecular Function

• GO:0004517 nitric-oxide synthase activity

Biological Process

• GO:0006809 nitric oxide biosynthetic process

External links

• PDB: RCSB:8fgt, PDBe:8fgt, PDBj:8fgt
• PDBsum: 8fgt
• PubMed: 37433128
• UniProt: P29474|NOS3_HUMAN Nitric oxide synthase 3 (Gene Name=NOS3)