Structure of PDB 8fda Chain D

Receptor sequence

>8fdaD (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]

LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQ
LAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMA
TFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLE
KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDQDSELL
SDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG
FSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVD
KGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA
GPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLID
SFKVKIKVRQAWREAQ

3D structure

PDB

8fda Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.14.19: steroid 17alpha-monooxygenase.
1.14.14.32: 17alpha-hydroxyprogesterone deacetylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	D	R96 I112 A113 W121 R125 A302 T306 H373 P434 F435 R440 C442 I443	R66 I82 A83 W91 R95 A265 T269 H336 P397 F398 R403 C405 I406
BS02	XPK	D	Y201 N202 I205 I206 R239 D298 A302 T306 V483	Y171 N172 I175 I176 R209 D261 A265 T269 V446
BS03	XPK	D	F42 L43 P44 N52 F53 L56 K59 L217 V218	F12 L13 P14 N22 F23 L26 K29 L187 V188

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0004508	steroid 17-alpha-monooxygenase activity
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829	lyase activity
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006694	steroid biosynthetic process
GO:0006702	androgen biosynthetic process
GO:0006704	glucocorticoid biosynthetic process
GO:0007548	sex differentiation
GO:0008202	steroid metabolic process
GO:0042445	hormone metabolic process
GO:0042446	hormone biosynthetic process
GO:0042448	progesterone metabolic process

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0030424	axon
GO:0043025	neuronal cell body

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fda, PDBe:8fda, PDBj:8fda
PDBsum	8fda
PubMed	37660137
UniProt	P05093\|CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase (Gene Name=CYP17A1)

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