Structure of PDB 8fd7 Chain D

Receptor sequence
>8fd7D (length=955) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDEPGSQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELN
WTSALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKID
LYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLS
DDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYK
KGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRV
FTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPM
VLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLI
LGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGV
GIPTINSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQD
ERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSE
TLKPDNFEESGYTFLAPRDYCSDLKPSDNNTEFLLNFNEFIDRKTPNNPS
CNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPK
EAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSK
AVEIYIQGKLLKPAVVGIKIDVNSWIENFTKRNSDVMDCVILDDGGFLLM
ANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAASK
QSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESK
GTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDC
GGVSG
3D structure
PDB8fd7 Structural basis for Ca V alpha 2 delta :gabapentin binding.
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBN D W207 Y219 Y238 R243 Y452 D454 D493 W171 Y183 Y202 R207 Y416 D418 D457
BS02 CA D S263 S265 T333 S227 S229 T297
External links
PDB RCSB:8fd7, PDBe:8fd7, PDBj:8fd7
PDBsum8fd7
PubMed36973510
UniProtP13806|CA2D1_RABIT Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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