Structure of PDB 8fay Chain D

Receptor sequence

>8fayD (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]

YHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVS
EVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRG
RRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATG
VVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAM
ELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLEPWDQTLGVVNFPRK
ASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEP
SEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALE
GQTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMG

3D structure

PDB

8fay Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)

Chain

Resolution

1.91 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.2.2.31: adenine glycosylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	Q139 Q141 G176 G178 Y179 Y180 Q293 K365 G396 L397 L398 H444 F446 S447 H448 S487 T488	Q56 Q58 G93 G95 Y96 Y97 Q210 K254 G285 L286 L287 H333 F335 S336 H337 S372 T373
BS02	dna	D	L137 Q138 Q139 T140 Q141 V142 R185 P213 G214 G216 Y218 T219 D236 G237 N238 R241	L54 Q55 Q56 T57 Q58 V59 R102 P130 G131 G133 Y135 T136 D153 G154 N155 R158
BS03	SF4	D	R245 C290 C297 C300 C306 R309 V355	R162 C207 C214 C217 C223 R226 V244

External links

PDB	RCSB:8fay, PDBe:8fay, PDBj:8fay
PDBsum	8fay
PubMed
UniProt	Q9UIF7\|MUTYH_HUMAN Adenine DNA glycosylase (Gene Name=MUTYH)

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