Structure of PDB 8f22 Chain D

Receptor sequence
>8f22D (length=205) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)) [Search protein sequence]
PIVQNGQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQDL
NTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVGQMREPRGSDIAGTTS
TLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKE
PFRDYVDRFYKTLRAEQASQATETLLVQNANPDCKTILKALGPGATLEEM
MTACQ
3D structure
PDB8f22 Structure of a benzosulfonamide based inhibitor - bound to a disulfide stabilised HIV-1 capsid hexamer
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XBQ D N53 L56 N57 M66 Q67 L69 K70 N74 A105 T107 Y130 N51 L54 N55 M64 Q65 L67 K68 N72 A96 T98 Y121
BS02 XBQ D Y169 L172 R173 Y160 L163 R164
Gene Ontology

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Biological Process
External links
PDB RCSB:8f22, PDBe:8f22, PDBj:8f22
PDBsum8f22
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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