Structure of PDB 8esq Chain D

Receptor sequence
>8esqD (length=427) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
IEKFSDLQLSENIQKAIKEMGFETMTEIQKRSIPPLLAGRDVLGAAKTGS
GKTLAFLIPTIEMLYALKFKPRNGTGVIIISPTRELALQIFGVAKELLKY
HHQTFGIVIGGANRRAEADKLVKGVNLLVATPGRLLDHLQNTKGFVFRNL
RSLVIDEADRILEIGFEDEMRQIMKILPSENRQTLLFSATQTTKVEDLAR
ISLKPGPLYVNVDEQGYVVVDSDKRFLLLFSFLKRNLKKKVIVFMSSCAS
VKYMAELLNYIDLPVLDLHGKQKQQRRTNTFFEFCNAEKGILLCTNVAAR
GLDIPAVDWIVQYDPPDDPRDYIHRVGGKSLMFLAPSELGFLRYLKTAKV
SLNEFEFPANKVANVQSQLEKLVSKNYYLQQSAKDGYRSYLQAYASYSLK
SIFDINKLDLAKVAKSFGFAHPPNVNI
3D structure
PDB8esq Chromatin localization of nucleophosmin organizes ribosome biogenesis.
ChainD
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D L175 N200 R202 K207 K210 N533 L88 N113 R115 K120 K123 N426
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8esq, PDBe:8esq, PDBj:8esq
PDBsum8esq
PubMed36423630
UniProtQ09916|HAS1_SCHPO ATP-dependent RNA helicase has1 (Gene Name=has1)

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