Structure of PDB 8ei5 Chain D

Receptor sequence
>8ei5D (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
RSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRR
RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN
PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK
DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGE
SIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE
KELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRI
RLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRL
DLPPYKSYEQLREKLLYAIEETE
3D structure
PDB8ei5 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainD
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D E650 F651 S654 W657 E158 F159 S162 W165
BS02 ZN D T799 T837 T307 T345
BS03 WHL D G667 E669 G175 E177
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei5, PDBe:8ei5, PDBj:8ei5
PDBsum8ei5
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

[Back to BioLiP]