Structure of PDB 8efi Chain D

Receptor sequence
>8efiD (length=371) Species: 9823 (Sus scrofa) [Search protein sequence]
TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYV
GDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTL
LTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLD
SGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTA
EREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNER
FRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTT
MYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQ
MWISKQEYDEAGPSIVHRKCF
3D structure
PDB8efi Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation.
ChainD
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP D G13 S14 L16 K18 G156 D157 K213 E214 G302 Y306 G9 S10 L12 K14 G152 D153 K209 E210 G298 Y302
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017022 myosin binding
Biological Process
GO:0007015 actin filament organization
GO:0010628 positive regulation of gene expression
GO:0033275 actin-myosin filament sliding
GO:0060047 heart contraction
GO:0090131 mesenchyme migration
Cellular Component
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8efi, PDBe:8efi, PDBj:8efi
PDBsum8efi
PubMed36459134
UniProtB6VNT8

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