Structure of PDB 8ed7 Chain D

Receptor sequence
>8ed7D (length=958) Species: 10090 (Mus musculus) [Search protein sequence]
ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLNHFP
FPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASEN
DMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNA
TCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPP
SILSLEFKNGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP
STQEWIVISYIFTLGIEKMREILMSGKLLQKVKVWLQEYWNVTDLIAILL
FSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMI
GKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWM
IYGEVFADQICKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKS
ISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCRDYGLKLFI
TDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE
EVNEREHS
3D structure
PDB8ed7 Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
ChainD
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D T133 Q134 L135 S136 P137 T138 R159 S161 E176 T5 Q6 L7 S8 P9 T10 R31 S33 E48
BS02 9Z9 D P1038 S1039 W1040 P785 S786 W787
BS03 9Z9 D M887 Y983 M636 Y730
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0051262 protein tetramerization
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ed7, PDBe:8ed7, PDBj:8ed7
PDBsum8ed7
PubMed36283409
UniProtQ5F4S7

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