Structure of PDB 8ec6 Chain D

Receptor sequence
>8ec6D (length=310) Species: 10090 (Mus musculus) [Search protein sequence]
FVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV
DGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRF
NKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGN
EYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLC
SIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDF
SGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFC
HDLVSLCNFH
3D structure
PDB8ec6 Molecular mechanism of glutaminase activation and filamentation and the role of filaments in mitophagy protection upon glutamine starvation
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 D R322 K325 R392 R99 K102 R169
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ec6, PDBe:8ec6, PDBj:8ec6
PDBsum8ec6
PubMed37857822
UniProtD3Z7P3|GLSK_MOUSE Glutaminase kidney isoform, mitochondrial (Gene Name=Gls)

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