Structure of PDB 8e6u Chain D

Receptor sequence
>8e6uD (length=1337) Species: 9606 (Homo sapiens) [Search protein sequence]
IKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPK
KHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDV
PNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMK
QVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYIL
DEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKER
GGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQV
ANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLL
TVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVD
IARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTW
DTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLR
ELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVT
FTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEE
EDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTT
CLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLL
LTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYV
LMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAALYFSD
FWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMHIFTI
SKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL
FRGAVYHSYLTIFGQIPGYIDGFPEWLTVLLLCLYLLFTNILLLNLLIAM
FNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRV
VLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQK
IEDISNKVDAMVDLLDLDGDSYHVNARHLLYPNCPVTRFPVPNEKVPWET
EFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGP
YTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRK
SIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFEN
LLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHA
CDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY
3D structure
PDB8e6u A unified mechanism for human TRPM2 activation, desensitization and inhibition
ChainD
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UOZ D T174 G175 A177 T212 M215 T275 Y295 G333 G335 T336 R358 T108 G109 A111 T146 M149 T209 Y229 G267 G269 T270 R292
BS02 UOZ D G1390 P1432 R1433 Y1485 N1487 H1488 G1224 P1266 R1267 Y1319 N1321 H1322
External links
PDB RCSB:8e6u, PDBe:8e6u, PDBj:8e6u
PDBsum8e6u
PubMed
UniProtO94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Gene Name=TRPM2)

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